選擇蛋白(Selectin)-調節免疫系統與腫瘤的細胞黏附分子
Selectin為細胞黏附分子其中一員，分為L-selectin (CD62L), P-selectin (CD62P), E-selectin (CD62E)，能與特定組織上的醣蛋白配體進行作用，常參與白血球和內皮細胞的黏附作用以及血小板的流動，在研究上與成型淋巴細胞歸巢、慢/急性發炎疾病以及癌症轉移有關，因此Selectin在近期常作為治療許多疾病的熱門標的。
Sino Biological可提供完整的Selectin和其對應Ligand的蛋白與抗體(更多資訊請參考下列表)
*10月底前部分蛋白商品可搭配買三送一活動，詳情請洽亞旭生物科技
本文轉載至原廠電子報:Sino Biological https://www.sinobiological.com/ 電子報原文
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Selectins are a family of cell adhesion molecules that participate in the early phases of leukocyte–endothelium interactions. They are required for the trafficking of innate immune system cells, T lymphocytes, and platelets.
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There are three groups of selectins: L-selectin (CD62L), P-selectin (CD62P), and E-selectin (CD62E). Each interacts with their respective glycoprotein (mucin) ligands on specific tissues. Selectins and their counter receptors/ligands are described in the table below.
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Cat#
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Tissue Distribution
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Protein Ligands
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Major Inducers
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P-selectin
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Activated endothelium and platelets
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PSGL-1, CD24
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Thrombin, Histamine, Complement derivatives Peroxides
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E-selectin
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Activated endothelium
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PSGL-1, ESL-1, L-Selectin
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IL-1, TNF-α, LPS
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L-selectin
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Memory lymphocytes, neutrophils, monocytes, macrophages, eosinophils
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PSGL-1, GlyCAM-1, MAdCAM-1, CD34, Podocalyxin
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IL-1, TNF-α, LPS, IFN-γ
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Selectins are actively involved in constitutive lymphocyte homing, chronic and acute inflammation, and cancer metastasis. Therefore, they are current hot targets for developing therapeutics to treat various diseases, such as sickle cell disease and malignancies. Sino Biological has a panel of high-quality reagents to support the study of selectins and ligands.
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Selectins and Ligands
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Sino Biological has developed a panel of high activity selectin and ligand proteins from various species to help study the biology of selectins.
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• Recommended Recombinant Selectins & Ligands Proteins
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Selectin/Ligand Antibodies
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Sino Biological has developed a comprehensive panel of antibodies targeting selectins and ligands, which can be used in FCM, ELISA, WB, and IP. Human, mouse, and rat selectin ELISA kits and ELISA pair sets are also available.
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