Selectins are a family of cell adhesion molecules that participate in the early phases of leukocyte–endothelium interactions. They are required for the trafficking of innate immune system cells, T lymphocytes, and platelets.
There are three groups of selectins: L-selectin (CD62L), P-selectin (CD62P), and E-selectin (CD62E). Each interacts with their respective glycoprotein (mucin) ligands on specific tissues. Selectins and their counter receptors/ligands are described in the table below.
Selectins are actively involved in constitutive lymphocyte homing, chronic and acute inflammation, and cancer metastasis. Therefore, they are current hot targets for developing therapeutics to treat various diseases, such as sickle cell disease and malignancies. Sino Biological has a panel of high-quality reagents to support the study of selectins and ligands.
Selectins and Ligands
Sino Biological has developed a panel of high activity selectin and ligand proteins from various species to help study the biology of selectins.
Sino Biological has developed a comprehensive panel of antibodies targeting selectins and ligands, which can be used in FCM, ELISA, WB, and IP. Human, mouse, and rat selectin ELISA kits and ELISA pair sets are also available.