|
Online View
|
|
|
|
B Cell Therapeutic Targets for Autoimmune Diseases: CD19, CD20 and CD38
|
|
|
|
Targeting B cell surface markers—such as CD19, CD20, and CD38—offers a way to regulate hyperactive immune responses underlying autoimmune diseases. Over 100 such diseases, including rheumatoid arthritis, multiple sclerosis, psoriasis, and type 1 diabetes, stem from immune system malfunctions, particularly T and B cell dysregulation, which causes the body to attack its own healthy cells. B cells drive disease progression by generating autoantibodies, releasing inflammatory cytokines, and functioning as antigen-presenting cells (APCs). Sino Biological offers high-quality CD19, CD20, and CD38 proteins. These proteins have been verified for high purity by HPLC and validated for high activity using ELISA, BLI, and SPR assays.
|
|
Click to Learn More about Autoimmune Diseases Targets 
|
|
|
|
Autoimmune Disease Research Solutions
|
|
Sino Biological provides comprehensive solutions for autoimmune research, offering target proteins, cytokines, kinases, and biomarker study reagents.
|
|
|
|
|
|
|
|
Broad Coverage of 46 Diseases
Rheumatoid arthritis, psoriasis, multiple sclerosis, etc.
|
|
Multiple Targets Available
Including immune cell targets, cytokines, and kinases.
|
|
High Quality Products
Target proteins with high activity, purity, and consistency
|
|
|
Learn More Our Solutions
|
|
|
|
Featured Products
|
|
CD19
|
|
CD19
|
|
Human CD19 Protein, HPLC-verified
Cat#: 11880-H02W
|
|
Human CD19 Protein, Site-Specific PE-Conjugated
Cat#: 11880-H08W1-SP
|
|
High Activity
|
|
High Activity
|
|
|
|
|
|
Loaded Biotinylated Inebilizumab derived Anti-CD19 Antibody, Human IgG1 on SA Biosensor, can bind Human CD19 Protein with an affinity constant of 0.575 nM as determined in BLI assay (Sartorius Octet RED384).
|
|
Flow cytometric analysis of anti-CD19 CAR expression. HEK293 cells were lentivirally transduced with anti-CD19 CAR. Sino’s 11880-H08W1-SP has a much higher fluorescence intensity than that of the competitor.
|
|
|
|
|
|
CD20
|
|
CD38
|
|
Human CD20 (Full Length) Protein-VLP
Cat#: 11007-HNAH
|
|
Human CD38 Protein, HPLC-verified
Cat#: 10818-H08H
|
|
High Activity
|
|
High Activity
|
|
|
|
|
|
Immobilized Recombinant Human CD20 (Full Length) Protein-VLP at 5 μg/mL (100 μL/well) can bind Ofatumumab.
|
|
Captured 68048-H001 (Daratumumab) on anti-human IgG Fc via CM5 Chip can bind CD38 with an affinity constant of 5.429 nM as determined in a SPR assay.
|
|
|
View More High Quality Autoimmune Disease Target Proteins
|
|
|
|
Don’t Miss Out!
|
|
|
|
Kinase Drug Discovery Solutions >>
|
|
Center for Bioprocessing (C4B)
US-Based Recombinant Production >>
|
|
|
|
|
|
