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| Bispecifics are challenging to manufacture, owing to their high complexity. To facilitate the rapid discovery and development of successful bispecific therapeutics, Sino Biological provides fast and efficient 雙特異性抗體(bsAb)生產服務 。based on its proprietary mammalian cell expression platforms and expertise in recombinant antibody production. Starting with antibody sequences, Sino Biological can deliver a wide range of bsAb formats, such as BiTE, IgG(H)-scFv, Diabody, CrossMab, DVD-IgG, and DutaMab. |
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服務特色
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Guaranteed
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Extensive Experience
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Numerous successful bsAb projects
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Almost any bsAb format can be customized
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Optimized HEK293/CHO Platforms
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Powerful QC Analysis
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Proprietary expression vectors, transfection reagents, culture media, etc.
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Purity, stability, solubility, affinity, and more (SDS-PAGE, UV, SEC-HPLC, endotoxin testing, ELISA, SPR, etc.)
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Various Purification Methods
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Protein Production & Antibody Development Expert
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Protein A/G/L, IEC, and SEC
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• Strong expertise
• 6,500+ recombinant proteins and 14,000+ antibodies library
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案例分享
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• Project: knobs-into-holes (KiH) bsAb
• Challenge: removal of oligomers & mis-matched contaminants
• Three-step purification: protein A-affinity, ion exchange, and gel filtration
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Purity: SDS-PAGE > 95%; SEC-HPLC: 96.6%
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• Project: IgG(H)-scFv
• Purification: protein A-affinity and gel filtration
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Purity: SDS-PAGE > 95%; SEC-HPLC: 98.5%
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