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The World Leader in Kinases
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Unlock Undruggable
Targets with Molecular
Glue Discovery Tools
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Molecular glue degraders (MGDs) are redefining targeted protein degradation. These typically monovalent, linker-free small molecules induce or stabilize interactions between an E3 ubiquitin ligase and a target protein, forming a ternary complex that can drive target ubiquitination and proteasomal degradation. By reprogramming E3 ligases to recognize neo-substrates, MGDs offer a promising strategy for addressing conventionally challenging targets.
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Sino Biological provides high-quality recombinant proteins across the ubiquitin-proteasome system to support molecular glue discovery. From compound-dependent E3 ligase recruitment and BLI or TR-FRET ternary complex assays to in vitro ubiquitination and DUB-mediated target stability studies, our validated reagents can help advance your targeted protein degradation program.
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Why Choose Sino Biological for Molecular Glue Discovery?
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Unlock Challenging Targets
Expand opportunities for conventionally difficult-to-drug proteins.
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End-to-End MGD Workflow
Support studies from E3 recruitment to target degradation.
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Broad E3 & DUB Portfolio
Explore diverse E3 ligases, complexes, and active DUBs.
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Activity-Validated Reagents
Ensure reliable research with activity-validated proteins.
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Featured Products
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Human AMSH/STAMBP Protein (Full Length, His Tag), Active
Cat#: A565-380H
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High Purity
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Specific Activity
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The purity of AMSH was determined to be >70% by densitometry, approx. MW 54 kDa.
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The specific activity of AMSH was determined to be 12 nmol /min/mg as per activity assay protocol.
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Human CRBN & DDB1 & CUL4A & RBX1 Protein (Full Length, His Tag)
Cat#: U273-380H
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High Purity
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Activity-Validated
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Subunit
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Observed MW (~kDa)
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Calculated MW (~kDa)
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CR8N
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58
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51
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DDB1
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128
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131
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CUL4A
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88
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87
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RBX1
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14
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12
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The purity of CRBN/DDB1/CUL4A/RBX1 was determined to be >70% by densitometry.
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 PROTAC-mediated ubiquitin reaction of BRD3 was used to confirm CRBN E3 ubiquitin ligase activity.
Lane 1: Marker.
Lane 2: CRBN Complex + BRD3 + Ub.
Lane 3: 0.1 µM PROTAC + CRBN Complex + BRD3 + Ub.
Lane 4: 0.4 µM PROTAC + CRBN Complex + BRD3 + Ub.
Lane 5: 2 µM PROTAC + CRBN Complex + BRD3 + Ub.
Lane 6: 0.4 µM PROTAC + BRD3 + Ub.
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More E3 ligases & Complexes
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Cat#
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Description
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Species
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Expression Host
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Sequence
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C268-30H
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STUB1 (CHIP) Protein
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Human
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E. coli
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Full Length
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C55-30G
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CRBN Protein
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Human
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Baculovirus-Insect Cells
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Full Length
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H265-381G
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HERC4, Active
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Human
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Baculovirus-Insect Cells
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642-end
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U272-380H
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VHL/ELOB/ELOC/CUL2/ RBX1 Complex
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Human
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Baculovirus-Insect Cells
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Full Length
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U274-34H
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CRBN/DDB1 Complex
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Human
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Baculovirus-Insect Cells
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Full Length
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U274-34G
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CRBN/DDB1 complex
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Human
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Baculovirus-Insect Cells
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1-442 (CRBN), 1-1140 (DDB1)
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More Deubiquitinating Enzymes
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Cat#
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Description
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Species
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Expression Host
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Sequence
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O585-30H
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OTULIN, Protein
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Human
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E. coli
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Full Length
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U511-380G
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USP11, Active
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Human
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Baculovirus-Insect Cells
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Full Length
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U512-31G
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USP12, Active
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Human
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Baculovirus-Insect Cells
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Full Length
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U515-380G
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USP15, Active
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Human
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Baculovirus-Insect Cells
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Full Length
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U516-381G
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USP16, Active
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Human
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Baculovirus-Insect Cells
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187-end
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North American Production
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Locally Produced. Globally Trusted.
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US-based Center for Bioprocessing (C4B) Redefining What’s Possible in Recombinant Protein & Antibody Production >>>
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Canada’s Largest Local Protein & Enzyme CRO 20+ Years of Excellence in Enzyme & Assay Development >>>
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