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Online View
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AI-Driven Antibody Discovery
with Cell-Free Expression From in silico design to functional Abs in just days.
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Accelerate antibody discovery with our cell-free protein synthesis platform (CFPS)—ideal for AI and computational biology teams. Sino Biological has developed a high-yield, E. coli-based lysate platform enabling rapid scFv and VHH expression without transfection or culturing. Go from in silico design to functional antibodies in days. We synthesize, express, purify, and validate AI-generated sequences through ELISA and BLI, ensuring specificity and detailed binding data. Cell-free expression also can overcome cellular limitations, making it possible to produce toxic or difficult-to-express targets. Let us handle the wet lab while you drive innovation—streamlining your path from sequence to insight.
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Partner with Us for Faster, Smarter Discovery 
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How Cell-Free Expression Platform Supports AI Discovery
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Antibody developability package available: aggregation, poly-reactivity, thermostability, self-association, hydrophobicity, colloidal stability, cross-interaction, cell-based assay
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Highlights of Cell-Free Expression Platform
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Fast and efficient
synthesis completed in just 3-5 hours
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High success rate
>99% success rate
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Consistency
comparable activity to proteins expressed in mammalian cells
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High throughput
>2,000/project
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Case Studies
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VHH Synthesized by CFPS with Comparable Binding Activity as that Expressed in Mammalian Cells
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Anti-IL6R VHH Binding (ELISA)
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Anti-TROP2 VHH Binding (ELISA)
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HTP scFv-His/VHH-His Synthesis for AI Screening
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Format: 2000+ scFv-His and VHH-His antibodies
Expression system: CFPS
Target: Finished expression and affinity analysis with different target proteins by BLI
Timeline: 3-4 weeks
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Reducing SDS-PAGE
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BLI Assay
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SEC-HPLC
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Don’t Miss Out!
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Kinase Drug Discovery Solutions >>
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Center for Bioprocessing (C4B)
US-Based Recombinant Production >>
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