Sino Biological | ADC藥物開發有望目標-CEACAMs

Sino Biological | ADC藥物開發有望目標-CEACAMs

2024.06.05

Sino Biological

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Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) 是CEA家族中之一的重要亞族。人類擁有12種,分別是CEACAM1 ,CEACAM3, 4, 5, 6, 7, 8, CEACAM16和CEACAM18, 19, 20和 CEACAM21. 實驗中發現CEACAM1、CEACAM5和CEACAM6,在幾種實體腫瘤中過度表達,成為腫瘤免疫治療的有希望的靶點,推動 bispecific antibodies (BsAbs), bispecific T cell engagers (BiTE), chimeric antigen receptor T cells (CAR-T) antibody-drug conjugates (ADCs). 等先進技術的發展。截至2023年11月,tusamitamab ravtansine為正在臨床試驗中評估的一種ADC,專門針對非小細胞肺癌(NSCLC)患者中的CEACAM5。Sino Biological認可CEACAMs的重要性,提供一系列經純度(SEC-HPLC)和生物活性驗證的重組CEACAM蛋白相對應的CEACAM抗體也經過嚴格的驗證以應用於特定實驗。

 

 

 

Sino Biological提供多種重組CEACAM蛋白與抗體,以協助CEACAMs相關研究。

 


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特色CEACAM重組蛋白產品

 


高純度


 經HPLC驗證


活性驗證


 多篇文獻引用

 

 

 

Human CEACAM-1/CD66a Protein

Human CEACAM-6/CD66c Protein

HPLC-verified Cat#: 10822-H08H

HPLC-verified Cat#: 10823-H08H

Activity-validated:
Ability to inhibit IL2 secretion by HuT 78 human cutaneous T cell lymphoma cells.

Activity-validated:
Immobilized human CEACAM6-his can bind human CEACAM8-his.

 

Human CEACAM-5/CD66e Protein

Human CEACAM-8/CD66b Protein

HPLC-verified Cat#: 11077-H41H-B

HPLC-verified Cat#: 11729-H08H

Purity:
≥ 95 % as determined by SEC-HPLC.

Purity:
≥ 90 % as determined by SEC-HPLC.

 

 

 

                               更多資訊

 

CEACAM重組蛋白全產品列表

 

特色CEACAM抗體產品

 

Anti-CEACAM-5/CD66e Antibody
Rabbit mAb

Anti-CEACAM-6/CD66c Antibody
Rabbit mAb

3 Citations Cat#: 11077-R327
Applications: IHC-P

2 Citations Cat#: 10823-R408
Applications: ELISA, FCM, ICC/IF

Immunochemical staining of human CEACAM5 in human colon carcinoma.

Immunofluorescence staining of Human CEACAM6 in SKBR3 cells.

 

更多CEACAM抗體資訊

 

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