|
|
|
|
|
|
| Carbonic Anhydrase (CA) 是碳酸氫鹽和質子濃度的重要調節劑，可調節細胞的 pH 值，而pH值的調節對細胞存活和增殖非常重要。 今年在Memorial Sloan Kettering Cancer Center開始的 CA IX 抑製劑與 Nivolumab 的聯合試驗顯示，sulfonamide的抑製劑和單株抗體抑制實體瘤中 CA IX 和 XII 蛋白活性，結果也比較好。 |
| 也有研究指出CA 的所有其他催化活性異構體 (I, II, III, IV, CAs VA–VB, CAs VI–VII, CAs XIII, 和 XIV) 也被發現在各種類型的癌症中失調。 因此在未來，這些CA蛋白可能有機會作為預後和診斷的生物標記。 |
| Carbonic anhydrases (CAs) |
 |
| Regulate tissue [CO2] |
|
Regulate tissue CO2/HCO3– |
|
Regulate pH transients |
|
Affect metabolic processes |
|
Promote HCO3– efflux through GABAA receptors |
|
| (Reference: doi.org/10.3390/molecules26216380) |
|
 |
|
| CA重組蛋白 |
| Cat# |
CAs |
Species |
Expression Host |
Purity |
Activity |
| 50660-M08H |
CA IX |
Mouse |
HEK293 Cells |
>95% |
Esterase Activity Validated |
| 10107-H02H |
CA IX |
Human |
HEK293 Cells |
>90% |
Esterase Activity Validated |
| 10617-H08H |
CA XII |
Human |
HEK293 Cells |
>97% |
Esterase Activity Validated |
| 10478-H08E |
CA II |
Human |
E. coli |
>96% |
Esterase Activity Validated |
|
| More (20+) Recombinant CA Proteins >> |
| CA抗體 |
| Cat# |
CAs |
Clonality |
Ig Type |
Application |
| 10107-RP02 |
CA IX |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P |
| 70028-T52 |
CA IX |
Rabbit PAb |
Rabbit IgG |
WB, ELISA, IP |
| 10617-MM07-P |
CA XII |
Mouse MAb |
Mouse IgG1 |
FCM |
| 50014-RP02 |
CA XII |
Rabbit PAb |
Rabbit IgG |
ELISA, IHC-P |
|
| More (80+) Antibodies for CAs >> |
|
|
