Sino Biological |IL-18:先天性與適應性免疫之間的聯繫

Sino Biological |IL-18:先天性與適應性免疫之間的聯繫


本文轉載自原廠電子報:Sino Biologica | | 電子報原文

IL-18: A Link between Innate and Adaptive Immunity
IL-18 is a pleiotropic pro-inflammatory cytokine. It belongs to the IL-1 superfamily and participates in both innate and acquired immunity. IL-18 mediates host immunity by regulating IFN-γ production in synergy with IL-12. IL18 also amplifies the innate immune response by other cytokines, such as GM-CSFTNF-α, and IL-1β.
IL-18 activates downstream signal transduction in a similar fashion as IL-1β. IL18 binds with its receptor IL-18 receptor α. Following that, an accessory protein, IL-18Rβ, is recruited to the complex, and the downstream cellular signal is initiated. IL-18 signaling is negatively regulated by the secreted antagonist receptor IL-18BP.
Comparison between IL-18 and IL-1β
Cytokine IL-18 IL-1β
Receptor IL-18Rα IL-1R1
Receptor Accessory Protein IL-18Rβ / IL-18RAcP IL-1RAcP
Receptor Antagonist IL-18BP IL-1RA
Decoy Receptor IL-18BP IL-1R2
Recent studies have implicated IL-18 pathway in autoimmune diseases, metabolic disorders, and cancers. Sino Biological has developed a panel of recombinant IL-18 and IL-18 receptor protein reagents to facilitate the study of the biology of IL-18.
Recombinant IL-18 Proteins
Sino biological has developed high bioactivity IL-18 proteins from multiple species. The activity of these proteins has been validated in IFN-γ induction experiments and binding assays against the IL-18 receptors.
h.png 10119-HNCE (Mature Form) m.png 50073-MNCE (Mature Form)
u4.png u5.png
Induce IFN Gamma Secretion Bind with IL-18Rα (Cat#: 50094-M38H)
Recombinant IL-18 Receptors
IL-18 receptor complex is a heterodimer containing an α (IL-18Rα) chain responsible for extracellular binding of IL-18 and a nonbinding, signal-transducing β (IL-18Rβ / IL-18RAcP) chain.
Recombinant IL-18Rα Recombinant IL-18Rβ
His Tag Fc Tag His Tag Fc Tag
h.png 11102-H08H 11102-H02H h.png 10176-H08H 10176-H02H
m.png 50094-M08H 50094-M38H m.png 50845-M08B
r.png 80191-R02H 80191-R08H rh.png 90122-C08H 90122-C02H
c.png 90121-C08H 90121-C02H Note: H: Human; R: Rat; M: Mouse;
C: Canine; Rh: Rhesus
Recombinant IL-18 Antagonist
IL-18BP neutralizes IL18 activity by binding with IL18.
Recombinant Human IL-18BP Recombinant Mouse IL-18BP
His Tag Fc Tag His Tag
10357-H08H 10357-H02H Isoform d 50206-M08H
IL-18 Detection Elisa Antibody Pair
Sino biological has developed high sensitivity ELISA pair sets for detection of IL-18. u6.png
Human IL-18 Matched ELISA Antibody Pair Set
Mouse IL-18 Matched ELISA Antibody Pair Set

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