本文轉載自原廠電子報:Sino Biologica | www.sinobiological.com | 電子報原文
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| IL-18 is a pleiotropic pro-inflammatory cytokine. It belongs to the IL-1 superfamily and participates in both innate and acquired immunity. IL-18 mediates host immunity by regulating IFN-γ production in synergy with IL-12. IL18 also amplifies the innate immune response by other cytokines, such as GM-CSF, TNF-α, and IL-1β. |
| IL-18 activates downstream signal transduction in a similar fashion as IL-1β. IL18 binds with its receptor IL-18 receptor α. Following that, an accessory protein, IL-18Rβ, is recruited to the complex, and the downstream cellular signal is initiated. IL-18 signaling is negatively regulated by the secreted antagonist receptor IL-18BP. |
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| Recent studies have implicated IL-18 pathway in autoimmune diseases, metabolic disorders, and cancers. Sino Biological has developed a panel of recombinant IL-18 and IL-18 receptor protein reagents to facilitate the study of the biology of IL-18. |
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| Recombinant IL-18 Proteins |
| Sino biological has developed high bioactivity IL-18 proteins from multiple species. The activity of these proteins has been validated in IFN-γ induction experiments and binding assays against the IL-18 receptors. |
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| Recombinant IL-18 Receptors |
| IL-18 receptor complex is a heterodimer containing an α (IL-18Rα) chain responsible for extracellular binding of IL-18 and a nonbinding, signal-transducing β (IL-18Rβ / IL-18RAcP) chain. |
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| Recombinant IL-18 Antagonist |
| IL-18BP neutralizes IL18 activity by binding with IL18. |
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| IL-18 Detection Elisa Antibody Pair |
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