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Interleukin 6 (IL-6)是一種促進發炎的細胞激素，參與免疫反應、造血、骨骼代謝和胚胎發育。在被微生物感染或其他發炎疾病的患者中可以觀察到IL-6的表現提高。因此將 IL-6作為標的對於診斷、管理和預防傳染病具有重要的臨床意義。
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| IL-6 的發炎功能是由soluble IL-6R (sIL-6R) 和gp130 的反式訊號傳遞所調節。透過活化發炎細胞因子 IL-1beta和TNF-alpha, 進而使 ADAM10 和 ADAM17 誘導 IL-6R 的蛋白水解切割，最後形成sIL-6R。 |
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sIL-6R的功能與大多數其他可溶性受體(例如 IL-1RA 和 IL-18BP)不同，sIL-6R 不是 IL-6 的抑製劑，反而會透過與 IL-6 和 gp130 形成複合物進而活化 IL-6 訊號傳遞。
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Sino Biological開發高品質重組 IL-6 和receptor蛋白以供相關細胞激素研究使用
Human IL-6R (cat#: 10398-H08H) 增強 M1 mouse myeloid leukemia cells的 IL-6 活性，ED50為 20-80 ng/mL。
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Sino Biological開發高品質重組 IL-6 和receptor蛋白以供相關細胞激素研究使用
Human IL-6R (cat#: 10398-H08H) 增強 M1 mouse myeloid leukemia cells的 IL-6 活性，ED50為 20-80 ng/mL。
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IL-6與Receptors與重組蛋白
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Sino Biological開發多物種(人類、小鼠、大鼠、猴、豬)重組IL-6細胞激素
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• Featured IL-6 Protein
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Human IL-6 Protein: 10395-HNAE
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High-purity
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Low-endotoxin
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Tag-free
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HPLC-verified
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> 95 % as determined by SDS-PAGE
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Cell proliferation assay using TF-1 human erythroleukemic cells
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Batch-to-batch Consistency
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• Bioactive Recombinant IL-6 from Multiple Species
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• Recombinant Membrane-bound IL-6 Receptor: IL-6R
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IL-6 demonstrates limited cross-species bioactivity. Human IL-6 can bind to both human and mouse IL-6R, but mouse IL-6 can only bind to mouse IL-6R.
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• Recombinant Gp130
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Gp130 is a common receptor and signal transducer shared by most IL-6 family cytokines.
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• More IL-6 Family Cytokines
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IL-6與其Receptors重組蛋白
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Sino Biological開發一系列IL-6與其Receptors抗體，可用於ELISA, WB, IHC-P, IP等應用
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• Neutralization Antibodies: IL-6 and IL-6R
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IL-6 Neutralizing Antibody
(Cat#: 10395-R508)
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IL-6R Neutralizing Antibody
(Cat#: 10398-MM08)
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Neutralize IL-6 induced proliferation in the T1165 mouse plasmacytoma cells. The IC50 is typically 80-320ng/mL
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IL-6-dependent Inhibition of cell proliferation is neutralized by Human IL-6R neutralizing Monoclonal Antibody. The IC50 is typically 0.15-0.6 μg/mL.
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ELISA Kits and ELISA Detection Pairs for IL-6 and Receptors
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