Sino Biological | IL-6:多效性發炎細胞激素

Sino Biological | IL-6:多效性發炎細胞激素

2022.08.16

Sino Biological

Interleukin 6 (IL-6)是一種促進發炎的細胞激素,參與免疫反應、造血、骨骼代謝和胚胎發育。在被微生物感染或其他發炎疾病的患者中可以觀察到IL-6的表現提高。因此將 IL-6作為標的對於診斷、管理和預防傳染病具有重要的臨床意義。

IL-6 的發炎功能是由soluble IL-6R (sIL-6R) 和gp130 的反式訊號傳遞所調節。透過活化發炎細胞因子 IL-1betaTNF-alpha, 進而使 ADAM10ADAM17 誘導 IL-6R 的蛋白水解切割,最後形成sIL-6R。
 

sIL-6R的功能與大多數其他可溶性受體(例如 IL-1RAIL-18BP)不同,sIL-6R 不是 IL-6 的抑製劑,反而會透過與 IL-6 和 gp130 形成複合物進而活化 IL-6 訊號傳遞。

10398-h08h

 

Sino Biological開發高品質重組 IL-6 和receptor蛋白以供相關細胞激素研究使用
Human IL-6R (cat#: 10398-H08H) 增強 M1 mouse myeloid leukemia cells的 IL-6 活性,ED50為 20-80 ng/mL。

 

Sino Biological開發高品質重組 IL-6 和receptor蛋白以供相關細胞激素研究使用
Human IL-6R (cat#: 10398-H08H) 增強 M1 mouse myeloid leukemia cells的 IL-6 活性,ED50為 20-80 ng/mL。

IL-6與Receptors與重組蛋白

Sino Biological開發多物種(人類、小鼠、大鼠、猴、豬)重組IL-6細胞激素

• Featured IL-6 Protein

Human IL-6 Protein: 10395-HNAE

 

High-purity

 

Low-endotoxin

 

Tag-free

 

HPLC-verified

10700-H03H

> 95 % as determined by SDS-PAGE

 

10584-HNAE

10584-HNAE

Cell proliferation assay using TF-1 human erythroleukemic cells

Batch-to-batch Consistency

• Bioactive Recombinant IL-6 from Multiple Species

Species

Cat#

Activity Validated

Human

10395-HNAE

Bind to Human IL-6R    Cell proliferation

Mouse

50136-MNAE

Cell proliferation

Rat

80076-RNAE

Cell proliferation

Rhesus

90197-CNAE

Cell proliferation

Sus scrofa (Pig)

62006-WNAE

Bind to Human IL-6R (10398-H08H)

• Recombinant Membrane-bound IL-6 Receptor: IL-6R

IL-6 demonstrates limited cross-species bioactivity. Human IL-6 can bind to both human and mouse IL-6R, but mouse IL-6 can only bind to mouse IL-6R.

Human IL-6 Receptor
10398-H08H

 

Mouse IL-6 Receptor
50280-M08H

 

Rat IL-6 Receptor
81072-R08H

Canine IL-6 Receptor
70117-D08H

 

Rhesus IL-6 Receptor
90324-C08H

 

 

• Recombinant Gp130

Gp130 is a common receptor and signal transducer shared by most IL-6 family cytokines.

Recombinant
Human gp130

 

Recombinant
Mouse gp130

 

Recombinant
Rat gp130

 

Recombinant
Rhesus gp130

• More IL-6 Family Cytokines

IL-11

 

LIF

 

OSM

 

CNTF

 

IL-31

 

IL-27

 

NNT-1

 

CT-1

 

IL-6與其Receptors重組蛋白

Sino Biological開發一系列IL-6與其Receptors抗體,可用於ELISA, WB, IHC-P, IP等應用

• Neutralization Antibodies: IL-6 and IL-6R

IL-6 Neutralizing Antibody
(Cat#: 10395-R508)

IL-6R Neutralizing Antibody
(Cat#: 10398-MM08)

IL-6 Neutralizing Antibody

IL-6R Neutralizing Antibody

Neutralize IL-6 induced proliferation in the T1165 mouse plasmacytoma cells. The IC50 is typically 80-320ng/mL

IL-6-dependent Inhibition of cell proliferation is neutralized by Human IL-6R neutralizing Monoclonal Antibody. The IC50 is typically 0.15-0.6 μg/mL.

 

ELISA Kits and ELISA Detection Pairs for IL-6 and Receptors

IL-6 ELISA Kit

 

IL-6R ELISA Kit

 

gp130 ELISA Kit

 

IL-6 Detection Pairs

 

IL-6R Detection Pairs

 

gp130 Detection Pairs

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