Sino Biological | IL-7: T細胞和B細胞發育的調節劑

Sino Biological | IL-7: T細胞和B細胞發育的調節劑

2022.08.24

Sino Biological

Sino Biological

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Interleukin-7 (IL-7)是 T 細胞和 B 細胞發育所必需的細胞激素,若缺乏 IL-7 會導致未成熟的免疫細胞停滯發育。由於 IL-7 在免疫和癌症發病機制中扮演重要的角色,因此針對各種疾病(如 HIV 感染、慢性感染、癌症和衰老)的標靶治療正在開發中。

 

IL-7屬於IL-2細胞激素超家族,包括 IL-2, IL-4, IL-9, IL-15 IL-21. IL7 與IL-7 受體 IL7RA/CD127 以及常見的 gamma chain受體(ɣc/IL2RG)結wq合, 進一步Jak/STAT 傳訊級聯。另外Thymic stromal lymphopoietin (TSLP) 也會與 IL7R 結合,與 TSLP 受體 (TSLPR/CRLF2) 形成異二聚體, TSLP 的訊號在決定淋巴細胞的命運和功能方面也有著重要作用。Sino Biological開發一系列高質量的重組 IL-7 和receptor蛋白,以提供相關細胞激素家族的研究

 

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Featured IL-7 & Receptor Proteins

Human IL-7 Protein | 11821-HNAE

High-purity

High Activity

Tag-free

HPLC-verified

11821-HNAE

11821-HNAE

Purity: ≥95% as determined by SDS-PAGE & HPLC

Cell proliferation assay using anti-CD3 antibody activated human peripheral blood mononuclear cell

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Human IL-7Rα Protein | 10975-H02H

10975-H02H

Immobilized IL-7 Protein (Cat#: 11821-HNAE) can bind IL-7RA

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Rat IL-7Rα Protein | 10975-H08H

10975-H08H

Purity:
>92% as determined by SDS-PAGE

Activity:
Ability to bind biotinylated mouse TSLP-his in functional ELISA

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