SinoBiological | 標靶治療的新前端技術:PROTAC技術

SinoBiological | 標靶治療的新前端技術:PROTAC技術

2024.12.18

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PROTAC®:
A New Frontier in Targeted Therapy
 

SignalChem Kinase
(Part of Sino Biological)

Comprehensive Solutions

Featured Products

Recombinant Production
(C4B US-based Center)

PROTAC® technology utilizes E3 ligases to selectively target and degrade pathogenic proteins, addressing drug resistance and “undruggable” targets. Key E3 ligases like CRBN and VHL drive breakthroughs in cancer and other therapies. SignalChem Biotech, part of Sino Biological, provides a wide range of ubiquitin enzymes, including CRBN/DDB1/Cul4A/Rbx1 complexes E1 activating enzymes, E2 conjugating enzymes, E3 ligases, and deubiquitinase enzymes. With over 30 E2 and 600 E3 combinations, SCB’s offerings support cutting-edge drug development.

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Featured Active Ubiquitin Enzymes

 

Wide Reaching Impact

Remarkable Specificity

Quality, Support, Trust, and Speed

 

Cereblon/DDB1/Cul4A/Rbx1 Complex | Cat#: U273-380H


PROTAC-mediated ubiquitin reaction of BRD3 was used to confirm CRBN E3 ubiquitin ligase activity.

View the Activity Assay Protocol  


The purity of CRBN/DDB1/CUL4A/RBX1 was determined to be >70% by densitometry.

View More Ubiquitin Products 

View Ubiquitins and PROTAC Poster

 

• Ubiquitin enzymes and PROTACs background
• PROTAC-related molecules and drug overview
• Ubiquitin products used and cited in prominent journals

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