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SignalChem Biotech’s highly active kinases, such as AKT, JAK, FLT play a pivotal role in advancing cancer drug discovery and development. These kinases, validated using ADP-Glo™ assays, deliver precise results in screenings, reducing risks in early drug discovery phases. With a catalog of over 1,100 wild-type and mutant kinases, custom enzyme development, and compound profiling services, SignalChem, part of Sino Biological, supports cancer drug development and discovery.
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Explore Our Kinase Drug Discovery Solutions 
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Kinase Activity is King at SignalChem Biotech
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Highly active kinases validated using ADP-Glo™ assays
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20+ years of expertise in enzyme and assay development
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Proprietary production and quality control platforms
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View Our 1,100+ Highly Active Kinases for Your Research
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Case Study
Better Kinase Activity Yields More Precise and Reliable IC50 Readouts |
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Comparison of inhibition profiles:
SignalChem AKT1 vs. competitor’s
• SignalChem AKT1 (Cat#: A16-10H) with high activity resulted in an excellent inhibition curve with a wide dynamic range.
• Competitor’s AKT1 product exhibited a shallow inhibition range, making it difficult to determine an accurate IC50 value. |
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Click for More Application Cases
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Product Validation Data
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Human CDK9 & Cyclin T1 Protein
Full Length, GST Tag
(Cat#: C40-18CG)
The specific activity of CDK9/CyclinT1 was determined to be 5.3 nmol/min/mg as per activity assay protocol.
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Human AKT1 (E17K) Protein
Full Length, GST Tag
(Cat#: A16-12G)
The specific activity of AKT1 (E17K) was determined to be 43 nmol /min/mg as per activity assay protocol.
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The World Leader in Kinases
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World’s Largest Catalog of Active Kinases
700+ wild-type & 400+ mutant kinases
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Custom Enzyme and Assay Development
Comprehensive biochemical & cellular assay platforms
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Compound Screening & Profiling Services
Average turnaround time of 2 weeks
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FDA-approved Protein Kinase Inhibitors
82 Approved Kinase Inhibitors & Products for Each Target
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Don’t Miss Out!
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 Browse human kinome and search products by protein kinase family Learn More
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View Our Highly Active Kinases in Research Applications Learn More
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See our active enzymes, signaling proteins, substrates and assay reagents Learn More
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