Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with mitogenic and angiogenic activities. The importance of VEGFs and receptors in angiogenesis, tumorigenesis, and neuroprotection makes them attractive targets for drug development.
The VEGF family members VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PlGF bind in specific patterns to three related receptor protein tyrosine kinases, VEGFR1/FLT1, VEGFR2/KDR, and VEGFR3/FLT4, and two non-tyrosine kinase transmembrane proteins, neuropilin-1 (NRP1) and neuropilin-2 (NRP2). The ligand-receptor binding induces the formation of homo- and heteromeric receptor complexes and activates downstream signaling. In addition to VEGF signaling, neuropilins also act as co-receptors to numerous other signaling pathways, including those triggered by Epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF), Hepatocyte Growth Factor (HGF), Insulin-like Growth Factor (IGF), Platelet-Derived Growth Factor (PDGF) and Transforming Growth Factor beta (TGFβ).
VEGF Family Ligands and Receptors
Sino Biological has over 65 recombinant VEGF & receptor proteins covering all VEGF family members and several isoforms of VEGF. A vast majority of these recombinant proteins were expressed in eukaryotic cells (human cells or insect cells), which ensures proper modification and higher activity of proteins.
Sino Biological has over 100 antibodies against VEGF & receptor proteins with validated activities in various applications, including western blotting, ELISA, immunohistochemistry, immunofluorescence, flow cytometry, and neutralization. ELISA kits and ELISA pair sets are also available.