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Online View
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Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with mitogenic and angiogenic activities. The importance of VEGFs and receptors in angiogenesis, tumorigenesis, and neuroprotection makes them attractive targets for drug development.
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The VEGF family members VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PlGF bind in specific patterns to three related receptor protein tyrosine kinases, VEGFR1/FLT1, VEGFR2/KDR, and VEGFR3/FLT4, and two non-tyrosine kinase transmembrane proteins, neuropilin-1 (NRP1) and neuropilin-2 (NRP2). The ligand-receptor binding induces the formation of homo- and heteromeric receptor complexes and activates downstream signaling. In addition to VEGF signaling, neuropilins also act as co-receptors to numerous other signaling pathways, including those triggered by Epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF), Hepatocyte Growth Factor (HGF), Insulin-like Growth Factor (IGF), Platelet-Derived Growth Factor (PDGF) and Transforming Growth Factor beta (TGFβ).
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VEGF Family Ligands and Receptors
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Sino Biological has over 65 recombinant VEGF & receptor proteins covering all VEGF family members and several isoforms of VEGF. A vast majority of these recombinant proteins were expressed in eukaryotic cells (human cells or insect cells), which ensures proper modification and higher activity of proteins.
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• High Activity
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Human / Cynomolgus VEGF165
(Cat#: 11066-HNAH)
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Human KDR
(Cat#: 10012-H08H)
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Cell proliferation assay using human umbilical vein endothelial cells (HUVEC)
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Inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC)
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• Recommended Recombinant VEGF & Receptor Proteins
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• More Recombinant VEGF & Receptor Proteins
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VEGF/VEGFR Antibodies
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Sino Biological has over 100 antibodies against VEGF & receptor proteins with validated activities in various applications, including western blotting, ELISA, immunohistochemistry, immunofluorescence, flow cytometry, and neutralization. ELISA kits and ELISA pair sets are also available.
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• Antibody List of CSFs and CSFR
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+1-215-583-7898
1400 Liberty Ridge Drive, Suite 101, Wayne, PA 19087 
